What is polynucleotide (PN)?

Polynucleotide (What is PN? It's a supplement that helps regenerate skin cells from within.

Medical procedures are constantly advancing and developing. One of the most popular and long-discussed skin care substances is "Polynucleotide (PN)," a substance extracted from salmon. It has the ability to regenerate and repair skin at the cellular level, stimulating the creation of new skin cells and natural collagen production. This results in healthier, younger-looking skin. This article will take you on a deep dive into PN: what it is, its advantages, who it's suitable for, and which procedures contain PN. Romrawin Clinic has compiled the information for you.

 

Delving deep into the causes of dull and aging skin.

The main causes of dull and aging skin are due to several factors, both internal and external, as follows:

• Sunlight and UV radiation This causes collagen breakdown and stimulates melanin production, accelerating premature aging and leading to wrinkles, freckles, age spots, and dehydration.
• Dust, smoke, and pollution. This causes skin inflammation, irritation, and increased dehydration, leading to wrinkles and a greater tendency to develop acne.
• Insufficient rest This prevents the skin from fully repairing and regenerating itself, resulting in the skin looking dull and aging prematurely.
• Accumulated stress This causes a decrease in collagen production and stimulates inflammation in the body, resulting in dull, weak, and easily deteriorated skin.
• Eating unhealthy food. For example, foods high in sugar, high in fat, or processed foods can cause skin inflammation, weaken the skin, and accelerate its aging process.
• Improper skin care For example, washing your face too harshly, exfoliating too frequently, not using sunscreen, and not using moisturizer can cause skin inflammation, irritation, dehydration, and premature aging.
• Increasing age This leads to decreased collagen production, slower skin cell turnover, and increased skin dehydration, resulting in dull, dry, and inelastic skin, as well as the formation of wrinkles. 

 

 

What is polynucleotide (PN)?

Polynucleotide, or PN, is a substance extracted from DNA fragments of salmon in natural seawater. This DNA molecule has a long, single strand structure. Through a process, highly pure PN is obtained, exhibiting a structure very similar to human DNA. Therefore, it can be effectively used to address various skin problems due to its biocompatible properties and lack of immune system rejection. 

PN is most often used as a key ingredient in skin booster procedures such as Rejuran or Puryal Densify. It's designed to improve skin condition and regenerate skin cells, stimulate collagen production, and strengthen the skin's protective barrier, resulting in hydrated, smooth, radiant, and healthy-looking skin from within.

 

How do polynucleotides (PN) work?

When polynucleotide (PN) is injected into the skin, it works by promoting the repair and regeneration of skin cells damaged by external factors such as sunlight, dust, smoke, and pollution. It also stimulates the creation of new skin cells and activates fibroblasts to produce more collagen and elastin. This results in smoother, firmer, more elastic, and naturally moisturized skin. Furthermore, it helps strengthen the skin barrier, reduce water loss, decrease inflammation, and minimize skin irritation. 

 

 

What are the benefits of polynucleotide (PN)?

• Helps to regenerate skin cells that have been damaged by sun exposure, pollution, or aging.
• Helps stimulate the production of collagen and elastin.
• Helps to moisturize and hydrate the skin from within.
• Helps to brighten, illuminate, and even out skin tone.
• Helps to tighten pores and smooth the skin.
• Helps reduce the appearance of shallow acne scars and stimulates the regeneration of new skin cells.
• Helps reduce the appearance of fine lines on the face.
• Helps reduce the appearance of dark spots and acne scars on the face.
• Helps to increase skin elasticity and firmness.
• Helps strengthen the skin's protective barrier.
• Helps reduce inflammation and irritation of the skin.

 

What are the key features of polynucleotides (PN)?

Polynucleotide (PN), or salmon extract, is a skin care ingredient with several notable features, including:

• It can restore damaged skin at the cellular level, making the skin look healthy and younger from within.
• It is well-compatible with the body because its structure is similar to human DNA, therefore it does not cause allergies or immune reactions.
• It is naturally biodegradable, leaving no residue in the body, and therefore does not cause any dangerous long-term side effects.
• Natural-looking results can be seen after injection, without stiffness or changes to the facial structure.
• Suitable for all skin types, including dry, oily, and even sensitive skin.
• It can be used in combination with other procedures to enhance the effectiveness of the results, depending on the physician's assessment.

 

 

Who is polynucleotide (PN) suitable for?

• Suitable for those with dry, rough, and dehydrated skin.
• Suitable for those with uneven skin tone, dull and lifeless skin.
• Suitable for those with fine lines or early wrinkles on the face.
• Suitable for those with enlarged pores and uneven skin texture.
• Suitable for those with acne scars and shallow blemishes. 
• Suitable for those with problems such as dark spots, acne scars, and redness from acne.
• Suitable for those with sagging and loose skin.
• Suitable for those with sensitive, easily irritated skin.
• Suitable for those with dull and neglected skin.
• Ideal for those who have trouble getting makeup to stay on or whose makeup flakes.
• Suitable for those who want to repair skin damaged by sun exposure, pollution, or other factors. 
• Suitable for those who want a natural-looking result without altering their existing facial features.
• Suitable for those who want to prepare their skin before a procedure or to rejuvenate their skin after a procedure. 

Before using the service, you should consult a doctor and inform them of your health history, including any pre-existing conditions, allergies, treatments, and medications you are currently taking.

 

Polynucleotide (PN) is not suitable for whom?

• Not suitable for individuals with a history of seafood allergies or salmon allergies.
• Not suitable for pregnant or breastfeeding women.
• Not suitable for individuals with infected wounds or open wounds in the area where the procedure will be performed.
• Not suitable for individuals with chronic skin inflammation or acne in the area to be treated.
• Not suitable for individuals with underlying medical conditions such as autoimmune diseases or immunodeficiency disorders.
• Not suitable for individuals with blood clotting problems or those taking blood thinners.
• Not suitable for those with noticeable wrinkles and deep lines, as PN is a substance focused on nourishing and restoring skin cells. 
• Not suitable for those with significant skin sagging who desire a noticeable skin lifting effect.

Before using the service, you should consult a doctor and inform them of your health history, including any pre-existing conditions, allergies, treatments, and medications you are currently taking.

 

What is the difference between polynucleotide (PN) and hyaluronic acid (HA)?

Polynucleotide (PN) and hyaluronic acid (HA) are widely used substances in the field of cosmetic medicine. These two substances have distinct mechanisms of action and properties, as follows:

• Polynucleotide (PN)

Polynucleotide (PN) is an extract from salmon DNA with a structure very similar to human DNA. Its high purity allows for optimal absorption by the body without immune rejection. PN's primary function is to regenerate and repair damaged skin cells from within, stimulate the creation of new skin cells, boost collagen production, and strengthen the skin's protective barrier. This results in more hydrated, radiant, elastic, brighter, and smoother skin. It is suitable for those with dull, weak, sensitive skin who desire overall skin rejuvenation. 

• Hyaluronic Acid (HA) 

Hyaluronic acid (HA) is a synthetic substance produced to mimic the HA found in the body. It's a key component in filler procedures, primarily responsible for retaining moisture, filling in wrinkles and deep lines, and adding volume to the skin. It also provides targeted lifting and contouring, resulting in a more voluminous, hydrated, plump, and sculpted face. It's ideal for those seeking to fill and improve facial structure, with noticeable results often seen after the first treatment.

 

What is the difference between polynucleotides (PN) and biostimulators?

Polynucleotides (PN) and biostimulators are widely used substances in the medical and cosmetic fields. These two types of substances have distinctly different mechanisms of action and properties, as follows:

• Polynucleotide (PN)

Polynucleotide (PN) is a highly purified extract from salmon DNA with a structure very similar to human DNA. This makes it highly compatible with the body and does not cause immune rejection. Its key properties include restoring and repairing skin cells damaged by various factors, stimulating the creation of new skin cells, boosting collagen production, and strengthening the skin's protective barrier. This results in more hydrated, radiant, elastic, brighter, and smoother skin. It is suitable for those with dull, weak, sensitive skin and those seeking overall skin rejuvenation. 

 

Biostimulator These are collagen-stimulating substances such as PLLA (Poly-L-Lactic Acid), CaHA (Calcium Hydroxyapatite), or PCL (Polycaprolactone). Their key feature is stimulating fibroblast cells to naturally increase collagen and elastin production, gradually restoring damaged skin structure. This isn't a temporary fix; it's a long-term collagen stimulation that results in firmer, tighter, more elastic, and healthier-looking skin. It's suitable for those with loose skin due to collagen deficiency, wrinkles, deep lines, and sagging skin, as well as those seeking long-lasting results.

 

 

In what medical procedures is polynucleotide (PN) used as an ingredient?

Polynucleotide (PN) is an extract from salmon that is used as a key ingredient in various procedures, including the following:

• They swear

Rejuran is a product from South Korea containing a high concentration of Polynucleotide (PN) – up to 2%. It's designed to improve skin quality, repair damaged skin cells, and stimulate new cell growth. It also promotes natural collagen production and the release of growth factors, resulting in hydrated, radiant, elastic, bright, and smooth skin from within. It can be injected into various areas such as the cheeks, forehead, around the eyes, nasolabial folds, marionette lines, and neck. 

โดย They swear Rejuran is administered in a syringe as a clear gel, ready for injection. A total of four Rejuran injections, spaced approximately 2-3 weeks apart, are generally recommended. The results can last for 3-6 months, depending on individual skin conditions.

 

What are the advantages of Rejuran?

• Rejuran contains PN as its main ingredient at a high concentration of 2%.
• Rejuran focuses on improving skin condition and restoring weakened skin cells from within.
• Rejuran can be injected in many areas, even sensitive areas such as around the eyes.
• Rejuran can show results from the very first treatment. 
• Rejuran is biodegradable and leaves no residue on the skin.
• Rejuran is certified by the Food and Drug Administration (FDA).

• Pluryal Densify

Puryal Densify is a product from [country name missing].Luxembourg Containing a main component of polynucleotide (PN) in the amount of 10. mg/ml combined with Hyaluronic Acid (HA) in a specific amount. 10 mg/ml and Mannitol dosage 40 mg/ml Designed to improve skin elasticity and firmness, while increasing hydration, fighting free radicals, and stimulating collagen production, resulting in moisturized, plump, firm, and smooth skin from within. It can be injected into various areas such as the cheeks, nasolabial folds, nasolabial folds, neck, back of the hands, and décolletage, but is not recommended around the eyes.

Puryal Densify is administered in a syringe as a clear gel, ready for injection. It is generally recommended to have three injections of Puryal Densify administered three weeks apart. The results can last from 3 to 6 months, depending on individual skin conditions.

 

What are the advantages of Pluryal Densify?

• Puryal Densify combines up to three ingredients: PN, HA, and Mannitol.
• Puryal Densify focuses on improving skin elasticity and firmness.
• Puryal Densify can show results from the very first treatment.
• Puryal Densify is biodegradable and leaves no residue on the skin.
• Puryal Densify can show results from the very first treatment.
• Puryal Densify is certified by the Food and Drug Administration (FDA) of Thailand.

 

How to prepare before receiving a Polynucleotide (PN) injection. 

• Before receiving PN injections, you should research the information and consult a doctor to assess your skin condition before the procedure.
• Before receiving PN injections, you should inform your doctor about your health information to prevent side effects.
• Before receiving PN injection, refrain from taking supplements or medications that increase bleeding risk, such as aspirin, ibuprofen, vitamin E, or fish oil.
• Before receiving PN injection, refrain from consuming alcoholic beverages and smoking.
• Before receiving PN injection, avoid laser treatments, waxing, hair removal, or any treatments that irritate the skin.
• Before receiving PN injection, refrain from scrubbing, exfoliating, or using products that promote skin cell turnover.
• Before receiving PN injections, get enough sleep and drink plenty of water. 
• Avoid wearing makeup on the day of your PN injection.

 

Polynucleotide (PN) injection procedure. 

• Consult a doctor.

Before starting any procedure, you should consult a doctor for a thorough examination, analysis, and evaluation of your skin condition. This will also include a discussion about your health history, such as any pre-existing conditions, allergies, current treatments, and medications you are taking.

• Plan the treatment appropriately.

After assessing the skin condition, the doctor will plan the treatment by selecting products suitable for the skin, determining the appropriate amount of substance to use, and precisely specifying the injection areas.

• Prepare the skin before the procedure.

Before the procedure, the medical assistant will clean the skin area to be injected to remove makeup and dirt, and apply a numbing cream to the injection area for approximately 30-45 minutes to minimize pain during the injection.

• The procedure is initiated by the physician.

The doctor will use a small needle to inject polynucleotide (PN) into the dermis layer of the skin using an appropriate injection technique. This procedure takes approximately 15–30 minutes, depending on the area being injected.

• The doctor gave advice on self-care.

After the procedure is complete, the doctor will provide instructions on self-care and post-injection guidelines to ensure effective results and minimize the risk of side effects.

 

How to care for yourself after receiving a Polynucleotide (PN) injection. 

• After receiving PN injection, avoid massaging, pressing, touching, or roughly handling the injection site.
• After PN injection, avoid heavy makeup on the injected area for approximately 12-24 hours.
• After receiving PN injection, avoid activities that cause excessive sweating or strenuous exercise.
• After receiving PN injection, refrain from consuming alcoholic beverages and smoking.
• After PN injection, avoid exposure to heat and sunlight. 
• After PN injection, apply a moisturizing cream or lotion to maintain skin hydration.
• After receiving PN injections, protect your skin from sunlight by applying sunscreen with an SPF of or higher.
• After receiving PN injection, stay in a cool, comfortable place to reduce swelling.
• After receiving PN injection, avoid laser treatments, waxing, hair removal, or any treatments that irritate the skin.
• After receiving PN injection, refrain from scrubbing, exfoliating, or using products that promote skin cell turnover.
• After receiving PN injections, you should eat nutritious food, get enough rest, and drink plenty of water. 
• After receiving PN injection, you should strictly follow your doctor's instructions.

 

 

The results obtained from polynucleotide (PN). 

• Helps to moisturize the skin, giving it a dewy, plump, and radiant glow.
• Helps to brighten the skin, giving it a radiant and even skin tone.
• Helps to make the skin smoother and more refined.
• Helps to minimize the appearance of pores and reduce the depth of acne scars.
• Helps to reduce the appearance of fine lines on the face.
• Helps to make the skin firm, bouncy, and elastic.
• Helps to fade dark spots, blemishes, redness, and acne scars.
• Helps the skin look radiant, bright, and not tired.
• Helps skin look healthy from within.
• It helps to strengthen the skin and make it more resistant to external factors.
• It helps makeup adhere better to the skin and makes makeup last longer.

 

Are polynucleotides (PN) dangerous? 

Generally, polynucleotide (PN) is a safe skin care ingredient if you choose genuine, FDA-approved products such as Rejuran or Pluryal Densify. This is because PN is highly pure, extracted from salmon DNA, which has a structure similar to human DNA. This allows for better bioavailability and effective use by the body to address various skin problems, reducing the risk of allergies or immune reactions.

 

Possible side effects after polynucleotide (PN) injection. 

Although polynucleotide (PN) is a well-compatible and relatively safe substance, minor side effects may occur after injection. These side effects are usually temporary and disappear within 1-3 days. The most common side effects after PN injection are as follows:

• A small, temporary bump may appear at the injection site, which usually disappears on its own within 1-2 days.
• Slight, temporary swelling may occur at the injection site and usually resolves on its own within 1-3 days.
• Slight, temporary redness may occur at the injection site, which usually resolves on its own within 1-2 days.
• Mild, temporary itching may occur at the injection site, which usually resolves on its own within 1-2 days.

 

Polynucleotide (PN) is a nourishing substance that helps repair damaged skin cells, stimulates collagen production, and improves skin quality. It also strengthens the skin's protective barrier and reduces inflammation from within. PN is often used as a key ingredient in skin treatments such as Rejuran or Pluryal Densify, which are crucial for achieving elastic, hydrated, radiant, and smooth skin with a natural appearance. Therefore, for those with dull, dry, dehydrated skin and enlarged pores who want to quickly restore skin quality, treatments containing PN are an effective option for achieving healthy-looking skin.

 

*Results may vary depending on individual skin conditions. Consult a doctor before undergoing this procedure.

*Terms and conditions apply as specified by the company.